Global gene expression differentiating pure bronchioloalveolar carcinoma from adenocarcinoma with bronchioloalveolar carcinoma features

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Global gene expression differentiating pure bronchioloalveolar carcinoma from adenocarcinoma with bronchioloalveolar carcinoma features.

OBJECTIVES Pure bronchioloalveolar carcinoma (BAC) is considered the early stage of lung adenocarcinoma, and is even regarded as lung adenocarcinoma in situ. This study was designed to investigate the differences in the gene expression of pure BAC and that of adenocarcinoma with bronchioloalveolar features and explore the mechanism of BAC progression to adenocarcinoma with bronchioloalveolar fe...

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Solitary nodular pure bronchioloalveolar carcinoma.

irregular borders ( fig. 2 ). It was histologically diagnosed as a pure nonmucinous bronchioloalveolar carcinoma (BAC) ( fig. 3 ). The patient was alive without signs of tumor recurrence 6 months later. BAC is known for low FDG uptake presumed to be secondary to the lower proliferation rate of these tumors [1] . Particularly low metabolic activity is observed in pure BAC, unifocal and mucin-con...

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Telomerase activation in adenocarcinoma-bronchioloalveolar carcinoma.

A t present, human bronchioloalveolar carcinoma (BAC) is a disease with an evolving definition. The clinical concept of BAC needs to be re-evaluated with careful attention to the 2004 World Health Organization (WHO) criteria [1] due to major clinical implications. Series published in the literature before 2000, i.e. before the WHO definition of BAC, had not discerned a specific survival advanta...

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A correlation between EGFR gene mutation status and bronchioloalveolar carcinoma features in Japanese patients with adenocarcinoma.

BACKGROUND The presence of epidermal growth factor receptor (EGFR) mutations in gefitinib-naive lung cancer patients has been reported to be higher in females, in non-smokers, in Japanese, and in adenocarcinoma patients, especially in bronchioloalveolar carcinoma (BAC). To further investigate the prevalence of EGFR mutations in relation to pathological factors, we evaluated EGFR mutations in se...

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Diagnosis and differentiation of bronchioloalveolar carcinoma from adenocarcinoma with bronchioloalveolar components with metabolic and anatomic characteristics using PET/CT.

UNLABELLED (18)F-FDG PET has been reported to have reduced sensitivity in detecting bronchioloalveolar carcinoma (BAC) versus lung cancers with other histologies. However, there are CT characteristics that are suggestive of BAC, and potentially these could be useful to refine diagnostic criteria so PET/CT can be more accurate in the diagnosis of BAC. We correlated tumor size and density obtaine...

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ژورنال

عنوان ژورنال: European Journal of Cardio-Thoracic Surgery

سال: 2012

ISSN: 1873-734X,1010-7940

DOI: 10.1093/ejcts/ezs427